Chapter 16: Problem 4
How do normal cells and cancer cells differ in terms of cell-cycle regulation?
Short Answer
Step by step solution
Key Concepts
These are the key concepts you need to understand to accurately answer the question.
Chapter 16: Problem 4
How do normal cells and cancer cells differ in terms of cell-cycle regulation?
These are the key concepts you need to understand to accurately answer the question.
All the tools & learning materials you need for study success - in one app.
Get started for freeThe following table shows neutral polymorphisms found in control families (those with no increased frequency of breast and ovarian cancer). Examine the data in the table and answer the following questions: (a) What is meant by a neutral polymorphism? (b) What is the significance of this table in the context of examining a family or population for \(B R C A 1\) mutations that predispose an individual to cancer? (c) Is the PM2 polymorphism likely to result in a neutral missense mutation or a silent mutation? (d) Answer part (c) for the PM3 polymorphism.
Explain the role of \(p 53\) protein in protecting normal cells against cancer. With respect to this protein and its function, explain how a normal cell turns cancerous.
Mention the causative agents of DNA lesions in the human body that can lead to cancer.
Describe kinases and cyclins. How do they interact to cause cells to move through the cell cycle?
Of the two classes of genes associated with cancer, tumorsuppressor genes and oncogenes, mutations in which group can be considered gain-of-function mutations? In which group are the loss-of-function mutations? Explain.
What do you think about this solution?
We value your feedback to improve our textbook solutions.