Chapter 16: Problem 3
What is the relationship between signal transduction and cellular proliferation?
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Key Concepts
These are the key concepts you need to understand to accurately answer the question.
Chapter 16: Problem 3
What is the relationship between signal transduction and cellular proliferation?
These are the key concepts you need to understand to accurately answer the question.
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Get started for freeA study by Bose and colleagues \((1998 . \text { Blood } 92: 3362-3367)\) and a previous study by Biernaux and others (1996. Bone Marrow Transplant 17: (Suppl. 3) S45-S47) showed that BCR-ABL fusion gene transcripts can be detected in 25 to 30 percent of healthy adults who do not develop chronic myelogenous leukemia (CML). Explain how these individuals can carry a fusion gene that is transcriptionally active and yet do not develop CML.
A genetic variant of the retinoblastoma protein, called PSM-RB (phosphorylation site mutated \(\mathrm{RB}\) ), is not able to be phosphorylated by the action of CDK4/cyclin D1 complex. Explain why PSM-RB is said to have a constitutive growth-suppressing action on the cell cycle.
If a cell suffers damage to its DNA while in S phase, how can this damage be repaired before the cell enters mitosis?
Explain the role of \(p 53\) protein in protecting normal cells against cancer. With respect to this protein and its function, explain how a normal cell turns cancerous.
What are the most significant environmental agents that contribute to human cancers?
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