Chapter 19: Problem 17
What are the most significant environmental agents that contribute to human cancers?
Chapter 19: Problem 17
What are the most significant environmental agents that contribute to human cancers?
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Get started for freeIn this chapter, we focused on cancer as a genetic disease, with an emphasis on the relationship between cancer, the cell cycle, and DNA damage, as well as on the multiple steps that lead to cancer. At the same time, we found many opportunities to consider the methods and reasoning by which much of this information was acquired. From the explanations given in the chapter (a) How do we know that malignant tumors arise from a single cell that contains mutations? (b) How do we know that cancer development requires more than one mutation? (c) How do we know that cancer cells often contain defects in DNA repair?
What are the differences between cancer driver mutations and passenger mutations? How can a passenger mutation become a driver mutation?
How do translocations such as the Philadelphia chromosome con- tribute to cancer?
Those who inherit a mutant allele of the \(R B 1\) tumor-suppressor gene are at risk for developing a bone cancer called osteosarcoma. You suspect that in these cases, osteosarcoma requires a mutation in the second \(R B 1\) allele, and you have cultured some osteosarcoma cells and obtained a cDNA clone of a normal human \(R B 1\) gene. A colleague sends you a research paper revealing that a strain of cancer-prone mice develops malignant tumors when injected with osteosarcoma cells, and you obtain these mice. Using these three resources, indicate which experiments you would perform to determine the following: (a) whether osteosarcoma cells carry two \(R B 1\) mutations, (b) whether osteosarcoma cells produce any pRB protein, (c) if the addition of a normal \(R B 1\) gene will change the cancercausing potential of osteosarcoma cells.
Define tumor-suppressor genes.Why is a mutation in a single copy of a tumor- suppressor gene expected to behave as a recessive gene?
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