Chapter 12: Problem 16
Most proteins have more leucine than histidine residues but more histidine than tryptophan residues. Correlate the number of codons for these three amino acids with this information.
Chapter 12: Problem 16
Most proteins have more leucine than histidine residues but more histidine than tryptophan residues. Correlate the number of codons for these three amino acids with this information.
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Get started for freeMessenger RNA molecules are very difficult to isolate from bacteria because they are quickly degraded. Can you suggest a reason why this occurs? Eukaryotic mRNAs are more stable and exist longer in the cell than do bacteria mRNAs. Is this an advantage or a disadvantage for a pancreatic cell making large quantities of insulin?
Describe the structure of RNA polymerase in bacteria. What is the core enzyme? What is the role of the \(\sigma\) factor?
When the amino acid sequences of insulin isolated from different organisms were determined, some differences were noted. For example, alanine was substituted for threonine, serine was substituted for glycine, and valine was substituted for isoleucine at corresponding positions in the protein. List the single-base changes that could occur in triplets to produce these amino acid changes.
One form of posttranscriptional modification of most eukaryotic RNA transcripts is the addition of a poly-A tail at the \(3^{\prime}\) -end. The absence of a poly-A tail leads to rapid degradation of the transcript. Poly-A tails of various lengths are also added to many bacterial RNA transcripts where, instead of promoting stability, they enhance degradation. In both cases, RNA secondary structures, stabilizing proteins, or degrading enzymes interact with poly-A tails. Considering the activities of RNAs, what might be the general functions of \(3^{\prime}\) -polyadenylation??
The mRNA formed from the repeating tetranucleotide UUAC incorporates only three amino acids, but the use of UAUC incorporates four amino acids. Why?
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