Embryogenesis and oncogenesis (generation of cancer) share a number of
features including cell proliferation, apoptosis, cell migration and invasion,
formation of new blood vessels, and differential gene activity. Embryonic
cells are relatively undifferentiated, and cancer cells appear to be
undifferentiated or dedifferentiated. Homeotic gene expression directs early
development, and mutant expression leads to loss of the differentiated state
or an alternative cell identity. M. T. Lewis [(2000). Breast Can. Res. \(2:
158-169]\) suggested that breast cancer may be caused by the altered expression
of homeotic genes. When he examined 11 such genes in cancers, 8 were
underexpressed while 3 were overexpressed compared with controls. Given what
you know about homeotic genes, could they be involved in oncogenesis?