In chickens, a key gene involved in sex determination has recently been
identified. Called \(D M R T 1\), it is located on the \(Z\) chromosome and is
absent on the W chromosome. Like \(S R Y\) in humans, it is male determining.
Unlike \(S R Y\) in humans, however, female chickens (ZW) have a single copy
while males
(ZZ) have two copies of the gene. Nevertheless, it is transcribed only in the
developing testis. Working in the laboratory of Andrew sinclair (a co-
discoverer of the human \(S R Y\) gene), Craig Smith and colleagues were able to
"knock down" expression of \(D M R T 1\) in \(Z Z\) embryos using RNA interference
techniques (see Chapter 17 ). In such cases, the developing gonads look more
like ovaries than testes [Nature 461: 267
(2009)]\(.\) What conclusions can you draw about the role that the \(D M R T 1\)
gene plays in chickens in contrast to the role the SRY gene plays in humans?