Chapter 5: Problem 20
Are mitotic recombinations and sister chromatid exchanges effective in producing genetic variability in an individual? in the offspring of individuals?
Chapter 5: Problem 20
Are mitotic recombinations and sister chromatid exchanges effective in producing genetic variability in an individual? in the offspring of individuals?
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Get started for freeA female of genotype \\[ \frac{a}{+}+b^{c} \\] produces 100 meiotic tetrads. Of these, 68 show no crossover events. Of the remaining 32,20 show a crossover between \(a\) and \(b, 10\) show a crossover between \(b\) and \(c,\) and 2 show a double crossover between \(a\) and \(b\) and between \(b\) and \(c .\) Of the 400 gametes produced, how many of each of the 8 different genotypes will be produced? Assuming the order \(a-b-c\) and the allele arrangement previously shown, what is the map distance between these loci?
Review the Chapter Concepts list on page \(138 .\) Most of these center around the process of crossing over between linked genes. Write a short essay that discusses how crossing over can be detected and how the resultant data provide the basis of chromosome mapping.
In a series of two-point mapping crosses involving five genes located on chromosome II in Drosophila, the following recombinant (single-crossover) frequencies were observed: $$\begin{array}{lc} p r-a d p & 29 \% \\ p r-v g & 13 \\ p r-c & 21 \\ p r-b & 6 \\ a d p-b & 35 \\ a d p-c & 8 \\ a d p-r g & 16 \\ v g-b & 19 \\ v g-c & 8 \\ c-b & 27 \end{array}$$ (a) Given that the adp gene is near the end of chromosome II (locus 83 ), construct a map of these genes. (b) In another set of experiments, a sixth gene, \(d\), was tested against \(b\) and \(p r\) $$\begin{array}{ll} d-b & 17 \% \\ d-p r & 23 \% \end{array}$$ Predict the results of two-point mapping between \(d\) and \(c, d\) and \(v g,\) and \(d\) and \(a d p\)
Why does more crossing over occur between two distantly linked genes than between two genes that are very close together on the same chromosome?
Phenotypically wild \(\mathrm{F}_{1}\) female Drosophila, whose mothers had light eyes \((l t)\) and fathers had straw \((s t w)\) bristles, produced the following offspring when crossed with homozygous lightstraw males: $$\begin{array}{lc} \text { Phenotype } & \text { Number } \\ \text { light-straw } & 22 \\ \text { wild } & 18 \\ \text { light } & 990 \\ \text { straw } & 970 \\ \text { Total } &{2000} \end{array}$$ Compute the map distance between the light and straw loci.
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