Chapter 21: Problem 16
It can be said that modern biology is experiencing an "omics" revolution. What does this mean? Explain your answer.
Chapter 21: Problem 16
It can be said that modern biology is experiencing an "omics" revolution. What does this mean? Explain your answer.
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Get started for freeTraditionally, gene sequence homology implied functional similarity. Even though two proteins may contain over 60 percent sequence identity, only about 38 percent have identical functions (Roy et al., 2008 ). In some cases, closely related homologs may engender completely different classes of proteins (enzymes). Consider the 3 D structure of two proteins with 60 percent homology with entirely different functions. Explain how different functions may evolve by discussing the position of the homologous amino acid track, its relation to nonhomologous tracks, and the role that chaperones (Chapter 14 ) may play in determining protein function.
What is bioinformatics, and why is this discipline essential for studying genomes? Provide two examples of bioinformatics applications.
BLAST searches and related applications are essential for analyzing gene and protein sequences. Define BLAST, describe basic features of this bioinformatics tool, and provide an example of information provided by a BLAST search.
What is noncoding RNA? What is its function?
Through the Human Genome Project (HGP), a relatively accurate human genome sequence was published in 2003 from combined samples from different individuals. It serves as a reference for a haploid genome. Recently, genomes of a number of individuals have been sequenced under the auspices of the Personal Genome Project (PGP). How do results from the PGP differ from those of the HGP?
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