Chapter 19: Problem 19
Describe the difference between an acute transforming virus and a virus that does not cause tumors.
Chapter 19: Problem 19
Describe the difference between an acute transforming virus and a virus that does not cause tumors.
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Get started for freeA genetic variant of the retinoblastoma protein, called PSMRB (phosphorylation site mutated \(\mathrm{RB}\) ), is not able to be phosphorylated by the action of CDK4/cyclin D1 complex. Explain why PSM-RB is said to have a constitutive growth-suppressing action on the cell cycle.
Distinguish between oncogenes and proto-oncogenes. In what ways can proto- oncogenes be converted to oncogenes?
Radiotherapy (treatment with ionizing radiation) is one of the most effective current cancer treatments. It works by damaging DNA and other cellular components. In which ways could radiotherapy control or cure cancer, and why does radiotherapy often have significant side effects?
List the functions of kinases and cyclins, and describe how they interact to cause cells to move through the cell cycle.
Do proto-oncogenes only have gain-of-function mutations but never loss-of- function ones to become oncogenes? Explain.
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