Chapter 18: Problem 7
(a) What are zygotic genes, and when are their gene products made? (b) What is the phenotype associated with zygotic gene mutations? (c) Does the maternal genotype contain zygotic genes?
Chapter 18: Problem 7
(a) What are zygotic genes, and when are their gene products made? (b) What is the phenotype associated with zygotic gene mutations? (c) Does the maternal genotype contain zygotic genes?
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Get started for freeList the main classes of zygotic genes. What is the function of each class of these genes?
The identification and characterization of genes that control sex determination has been a focus of investigators working with \(C .\) elegans. As with Drosophila, sex in this organism is determined by the ratio of \(X\) chromosomes to sets of autosomes. A diploid wild-type male has one \(X\) chromosome and a diploid wild-type hermaphrodite has two X chromosomes. Many different mutations have been identified that affect sex determination. Loss- of-function mutations in a gene called her-1 cause an XO nematode to develop into a hermaphrodite and have no effect on \(\mathrm{XX}\) development. (That is, \(\mathrm{XX}\) nematodes are normal hermaphrodites.) In contrast, loss- offunction mutations in a gene called tra-I cause an XX nematode to develop into a male. Deduce the roles of these genes in wild-type sex determination from this information.
Carefully distinguish between the terms differentiation and determination. Which phenomenon occurs initially during development?
In this chapter, we have focused on large-scale as well as the inter- and intracellular events that take place during embryogenesis and the formation of adult structures. In particular, we discussed how the adult body plan is laid down by a cascade of gene expression, and the role of cell-cell communication in development. Based on your knowledge of these topics, answer several fundamental questions: (a) How do we know how many genes control development in an organism like Drosophila? (b) What experimental evidence demonstrates that molecular gradients in the egg control development? (c) How did we discover that selector genes specify which adult structures will be formed by body segments? (d) How did we learn about the levels of gene regulation involved in vulval development in \(C .\) elegans? (e) How do we know that eye formation in all animals is controlled by a binary switch gene?
(a) What are maternal-effect genes? (b) When are gene products from these genes made, and where are they located? (c) What aspects of development do maternal-effect genes control? (d) What is the phenotype of maternal-effect mutations?
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