Chapter 18: Problem 20
In Arabidopsis, flower development is controlled by sets of homeotic genes. How many classes of these genes are there, and what structures are formed by their individual and combined expression?
Chapter 18: Problem 20
In Arabidopsis, flower development is controlled by sets of homeotic genes. How many classes of these genes are there, and what structures are formed by their individual and combined expression?
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Get started for free(a) What are maternal-effect genes? (b) When are gene products from these genes made, and where are they located? (c) What aspects of development do maternal-effect genes control? (d) What is the phenotype of maternal-effect mutations?
Dominguez et al. (2004) suggest that by studying genes that determine growth and tissue specification in the eye of Drosophila, much can be learned about human eye development. (a) What evidence suggests that genetic eye determinants in Drosophila are also found in humans? Include a discussion of orthologous genes in your answer. (b) What evidence indicates that the eyeless gene is part of a developmental network? (c) Are genetic networks likely to specify developmental processes in general? Explain fully and provide an example.
Carefully distinguish between the terms differentiation and determination. Which phenomenon occurs initially during development?
Distinguish between the syncytial blastoderm stage and the cellular blastoderm stage in Drosophila embryogenesis.
Embryogenesis and oncogenesis (generation of cancer) share a number of features including cell proliferation, apoptosis, cell migration and invasion, formation of new blood vessels, and differential gene activity, Embryonic cells are relatively undifferentiated, and cancer cells appear to be undifferentiated or dedifferentiated. Homeotic gene expression directs early development, and mutant expression leads to loss of the differentiated state or an alternative cell identity. M. T. Lewis (2000. Breast Can. Res. \(2: 158-169\) ) suggested that breast cancer may be caused by the altered expression of homeotic genes. When he examined 11 such genes in cancers, 8 were underexpressed while 3 were overexpressed compared with controls. Given what you know about homeotic genes, could they be involved in oncogenesis?
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