Chapter 15: Problem 8
What is meant by a conditional mutation?
Chapter 15: Problem 8
What is meant by a conditional mutation?
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Get started for freeSuppose you are studying a DNA repair system, such as the nucleotide excision repair in vitro. By mistake, you add DNA ligase from a tube that has already expired. What would be the result?
Why is a random mutation more likely to be deleterious than beneficial?
Acridine dyes induce frameshift mutations. Why are frameshift mutations likely to be more detrimental than point mutations, in which a single pyrimidine or purine has been substituted?
It has been noted that most transposons in humans and other organisms are located in noncoding regions of the genome \(-\) regions such as introns, pseudogenes, and stretches of particular types of repetitive DNA. There are several ways to interpret this observation. Describe two possible interpretations. Which interpretation do you favor? Why?
Mutations in the \(I L 2 R G\) gene cause approximately 30 percent of severe combined immunodeficiency disorder (SCID) cases. These mutations result in alterations to a protein component of cytokine receptors that are essential for proper development of the immune system. The \(I L 2 R G\) gene is composed of eight exons and contains upstream and downstream sequences that are necessary for proper transcription and translation. Below are some of the mutations observed. For each, explain its likely influence on the \(I L 2 R G\) gene product (assume its length to be 375 amino acids). (a) Nonsense mutation in coding regions (b) Insertion in Exon 1 , causing frameshift (c) Insertion in Exon \(7,\) causing frameshift (d) Missense mutation (e) Deletion in Exon 2 , causing frameshift (f) Deletion in Exon 2 , in frame (g) Large deletion covering Exons 2 and 3
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