Chapter 15: Problem 5
Most mutations are thought to be deleterious. Why, then, is it reasonable to state that mutations are essential to the evolutionary process?
Chapter 15: Problem 5
Most mutations are thought to be deleterious. Why, then, is it reasonable to state that mutations are essential to the evolutionary process?
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Get started for freePresented here are hypothetical findings from studies of heterokaryons formed from seven human xeroderma pigmentosum cell strains: $$\begin{array}{lccccccc} & X P 1 & X P 2 & X P 3 & X P 4 & X P 5 & X P 6 & X P 7 \\ X P 1 & \- & & & & & & \\ X P 2 & \- & \- & & & & & \\ X P 3 & \- & \- & \- & & & & \\ X P 4 & \+ & \+ & \+ & \- & & & \\ X P S & \+ & \+ & \+ & \+ & \- & & \\ X P 6 & \+ & \+ & \+ & \+ & \- & \- & \\ X P 7 & \+ & \+ & \+ & \+ & \- & \- & - \end{array}$$ These data are measurements of the occurrence or nonoccur- rence of unscheduled DNA synthesis in the fused heterokaryon. None of the strains alone shows any unscheduled DNA synthesis. Which strains fall into the same complementation groups? How many different groups are revealed based on these data? What can we conclude about the genetic basis of XP from these data?
What is meant by a conditional mutation?
In this chapter, we focused on how gene mutations arise and how cells repair DNA damage. At the same time, we found opportunities to consider the methods and reasoning by which much of this information was acquired. From the explanations given in the chapter, (a) How do we know that mutations occur spontaneously? (b) How do we know that certain chemicals and wavelengths of radiation induce mutations in DNA? (c) How do we know that DNA repair mechanisms detect and correct the majority of spontaneous and induced mutations?
It has been noted that most transposons in humans and other organisms are located in noncoding regions of the genome \(-\) regions such as introns, pseudogenes, and stretches of particular types of repetitive DNA. There are several ways to interpret this observation. Describe two possible interpretations. Which interpretation do you favor? Why?
Describe how the Ames test screens for potential environmental mutagens. Why is it thought that a compound that tests positively in the Ames test may also be carcinogenic?
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