Question

If both copies of a light chain gene and a heavy-chain gene recombined in each (diploid) B cell, how would this affect B cell development and function?

Short answer

In the given case, each B cell would generate a different combination of light and heavy chains for its antigen receptor, resulting in four distinct receptors. If any of the lymphocytes were self-reactive, they would be removed in the formation of self-tolerance.

Step-by-step solution

Lymphocytes

Lymphocytes are white blood cells that combat infection and are an essential aspect of the human immune system. They are created in response to a virus as an invading foreign particle. B cells and T cells are the two kinds of lymphocytes.

B cells

B cells, commonly known as B lymphocytes, develop in the bone marrow and produce antibodies. T cells assist B cells in producing antibodies by activating them. Plasma cells and memory cells are also produced by B cells.

Immunoglobin

Immunoglobulins are unique proteins produced by white blood cells that attach to chemicals on pathogens' surfaces. As a result, the immune system can identify and eliminate only those items associated with antibodies.

They produce a vast number of receptors (and antibodies), which would result in a greater number of B cells being destroyed and fewer B cells being able to respond to a foreign antigen.