Question

Vinblastine is a standard chemotherapeutic drug used to treat cancer. Because it interferes with the assembly of microtubules, its effectiveness must be related to

(A) disruption of mitotic spindle formation.

(B) suppression of cyclin production

(C) myosin denaturation and inhibition of cleavage furrow formation

(D) inhibition of DNA synthesis

Short answer

(A) The option “disruption of mitotic spindle formation” is false.

(B) The option “suppression of cyclin production” is true.

(C) The option “myosin denaturation and inhibition of cleavage furrow formation” is false.

(D) The option “inhibition of DNA synthesis” is false.

Step-by-step solution

Description of cancer cells

Cancer cells are continuously increasing cell that divides in an uncontrolled manner. The rapid division is due to the loss of cell cycle regulation. It results in the formation of tumor mass by uncontrolled growth of the cells.

Explanation of option (A)

Mitotic spindle formation is the process of formation of spindles that separates the chromosomes. The drugs that can inhibit the cancer cell mechanism have a more profound tool than the disruption of mitotic spindle fiber formation.

The effectiveness of vinblastine is not related to the disruption of spindle fiber formation.

Therefore, the given statement is false.

Explanation of option (B)

Vinblastine is the drug that is a cell cycle phase-specific medication. It particularly acts on the microtubular protein and stops the metaphase stage of the cell cycle. Cyclins are substance that binds to cyclin-dependent kinases and promotes the various levels of the cell cycle.

Vinblastine acts by reducing or suppressing cyclin production, which in turn stops the cell cycle. The vinblastine must suppress the activity of cyclin to control the growth of cancer cells.

Therefore, the given statement is true.

Explanation of option (C)

Myosin is the protein that is involved in the movement of muscles cells. The denaturation affects the muscle texture. The cleavage furrow formation is the last step of the cell cycle known as cytokinesis.

Vinblastine activity is related to the metaphase of the cycle.

Therefore, the given statement is false.

Explanation of option (D)

The blockage of DNA synthesis is the primary therapeutic strategy used to treat diseases like cancer. An example of a DNA synthesis inhibitor is Zidovudine.

Vinblastine is not a DNA inhibitor. It acts in the other stage of the cell cycle.

Therefore, the given statement is false.