Question

Calculate the dosages as indicated. Use the labels where provided. Order: \(2 \mathrm{~g}\) Pronestyl in \(500 \mathrm{~mL}\) D5W to infuse at \(2 \mathrm{mg} / \mathrm{min}\). Determine the rate in \(\mathrm{mL} / \mathrm{hr}\).

Short answer

The rate should be 30 mL/hr.

Step-by-step solution

Convert grams to milligrams

Recognize that the order is given in grams but needs to be converted to milligrams. Since there are 1000 milligrams in a gram, multiply the given grams by 1000.\[ 2 \text{ g} = 2 \times 1000 \text{ mg} = 2000 \text{ mg} \]

Find drug concentration in mg/mL

The concentration is calculated by dividing the total milligrams of Pronestyl by the total volume in milliliters.\[ \text{Concentration} = \frac{2000 \text{ mg}}{500 \text{ mL}} = 4 \text{ mg/mL} \]

Determine desired rate in mL/min

The rate is given in mg/min, which should be converted to mL/min using the drug concentration. The infusion rate needed is 2 mg/min.\[ \text{Rate in mL/min} = \frac{2 \text{ mg/min}}{4 \text{ mg/mL}} = 0.5 \text{ mL/min} \]

Convert rate to mL/hr

Convert the rate from mL/min to mL/hr by multiplying by 60 (the number of minutes in an hour).\[ \text{Rate in mL/hr} = 0.5 \text{ mL/min} \times 60 \text{ min/hr} = 30 \text{ mL/hr} \]

Key concepts

Medication Concentration

When working with medication dosages, understanding concentration is vital. Concentration refers to the amount of a drug within a specific volume of solution. This tells us how much active ingredient is present in each milliliter of a liquid preparation.
For instance, consider you have an order for Pronestyl, which states 2 grams in 500 milliliters of D5W. The first step is to convert grams into milligrams. We do this because there are 1,000 milligrams in a gram, thus 2 grams equals 2,000 milligrams. We then find the drug's concentration by dividing the total milligrams by the total volume in milliliters, which gives us 4 mg/mL. This concentration is crucial for further calculations, as it helps determine how fast the medication should be infused to achieve the desired therapeutic effect.
Correctly calculating concentration ensures that the patient receives the right dose, neither too little which risks inefficacy, nor too much which can be harmful.

Unit Conversion

Unit conversion is a common and necessary task in dosage calculations. It involves changing one unit of measurement into another, such as converting grams into milligrams or minutes into hours.
The ability to convert units accurately ensures precision in medication administration. In our example, the initial drug amount is provided in grams. Since medical dosages often require milligrams, we convert grams to milligrams—remembering that 1 gram equals 1,000 milligrams. Therefore, 2 grams of Pronestyl becomes 2,000 milligrams. This conversion allows us to compute how much of the medication is needed to achieve the specified dosage.
Similarly, the desired infusion rate is provided in mg/min, but devices like infusion pumps usually require the rate in mL/hr. Converting between these units is essential to set the device correctly, ensuring the medication is delivered at the right pace for optimal treatment.

Infusion Rate Calculation

Calculating the infusion rate is an essential step in administering intravenous medications. The infusion rate determines how quickly a medication will be delivered to the patient, measured in milliliters per hour (mL/hr).
To find this rate, you start with the desired dosage in the problem—in this case, 2 mg/min. Using the previously calculated concentration of 4 mg/mL, you can determine how many milliliters per minute are needed. You achieve this by dividing the desired dose (2 mg/min) by the concentration (4 mg/mL), resulting in 0.5 mL/min. Then, convert this rate to mL/hr since that's a more practical measure for infusion devices. Since there are 60 minutes in an hour, multiply the result by 60 to find the infusion rate: 0.5 mL/min turns into 30 mL/hr.
This calculation ensures that the infusion device administers the precise volume needed per hour, providing the patient with a steady and controlled delivery of the medication.