Question

Calculate the dosages as indicated. Use the labels where provided. Esmolol $1.5\mathrm{g}$ in $250\mathrm{mL}$ D5W has been ordered at a rate of $100\mathrm{mcg}/\mathrm{kg}/\min$ for a client weighing $102.4\mathrm{kg}.$ Determine the following: a. dosage in $\mathrm{mcg}/\min$ b. rate in $\mathrm{mL}/\mathrm{hr}$

Short answer

a) 10,240 mcg/min, b) 102.42 mL/hr

Step-by-step solution

Calculate Dosage in mcg/min

First, calculate the dosage of esmolol in micrograms per minute. The ordered dosage is 100 mcg/kg/min. Multiply this by the patient's weight to find the dosage per minute: $$\text{Dosage}=100\text{ mcg/kg/min}\times 102.4\text{ kg}$$$$\text{Dosage}=10240\text{ mcg/min}$$

Convert Drug Concentration to mcg/mL

Next, convert the concentration of esmolol from grams to micrograms and then calculate the concentration per mL. Since 1 g = 1,000,000 mcg, the concentration in the bag is: $$1.5\text{ g}=1,500,000\text{ mcg}$$Thus, the concentration is: $$\frac{1,500,000\text{ mcg}}{250\text{ mL}}\approx 6000\text{ mcg/mL}$$

Calculate Rate in mL/hr

Now, calculate the rate in mL per hour. Use the dosage calculated in step 1 and the concentration calculated in step 2:$$\text{Rate}=\frac{10240\text{ mcg/min}}{6000\text{ mcg/mL}}\approx 1.707\text{ mL/min}$$Convert this rate to mL/hr by multiplying by 60:$$1.707\text{ mL/min}\times 60\text{ min/hr}=102.42\text{ mL/hr}$$

Key concepts

Understanding Drug Concentration

Drug concentration is the amount of a drug present in a given volume of solution. When dealing with medications, understanding concentration is crucial in calculating how much drug a patient receives. For instance, in our esmolol example, the concentration is given as 1.5 grams dissolved in 250 milliliters of a solution. To better work with smaller, more precise measurements typical in medical settings, we convert grams to micrograms because 1 gram equals 1 million micrograms. Therefore, 1.5 grams of esmolol translates to 1,500,000 micrograms in total. Dividing this number by 250 milliliters gives us the concentration per milliliter, which is 6000 micrograms per milliliter. This conversion is vital for calculating the correct dosage a patient receives, ensuring effective treatment while preventing overdose. Precise drug concentration calculations help medical professionals determine the exact milliliters required for administration.

Esmolol Dosage Calculations

Calculating the dosage of esmolol involves understanding how the prescribed amount relates to the patient's weight. Esmolol is administered as a weight-based dosage, which means the amount of drug given is proportional to the patient's weight. Let's break it down using the exercise scenario. Here, the esmolol dosage prescribed is 100 micrograms per kilogram per minute. For a patient weighing 102.4 kilograms, the calculation for the total dosage per minute is:

• Multiply the dosage per kilogram (100 mcg/kg/min) by the patient's weight (102.4 kg).
• The result is 10,240 micrograms per minute.

This dosage reflects the total amount of esmolol the patient needs every minute to ensure consistent therapeutic effects. This calculation is crucial, especially since an incorrect dosage could result in under-treatment or potential side effects due to overtreatment.

Weight-Based Dosages Explained

Weight-based dosages play an essential role in individualized patient care. Such calculations help determine the precise amount of medication required for effectiveness while considering the patient's unique physiological makeup. In weight-based dosage calculations, factors like body weight, age, and sometimes body surface area are taken into account. For esmolol, the calculation involves multiplying the dosage per kilogram by the total body weight. This central approach is widely used in medication dosing for drugs with narrow therapeutic indexes, such as esmolol, where the precision of dose is critical. By employing weight-based dosing, healthcare professionals can tailor treatments with more accuracy, ensuring that patients receive the optimal amount of medication for their specific needs. This method minimizes risks of adverse reactions while maximizing the drug's efficacy, providing a valuable safeguard in personalized medicine.