Question

Calculate the dosages as indicated. Use the labels where provided. Order: Esmolol \(2.5 \mathrm{~g}\) in \(250 \mathrm{~mL} 0.9 \% \mathrm{NS}\) at \(30 \mathrm{~mL} / \mathrm{hr}\). Calculate the following: a. \(\mathrm{mg} / \mathrm{hr}\) b. \(\mathrm{mg} / \mathrm{min}\)

Short answer

a. 300 mg/hr b. 5 mg/min

Step-by-step solution

Calculate concentration

First, determine the concentration of Esmolol in the solution. The order specifies that there are \(2.5 \text{ g}\) of Esmolol in \(250 \text{ mL}\) of solution. To find the concentration in mg/mL, convert grams to milligrams: \(2.5 \text{ g} = 2500 \text{ mg}\). Hence, the concentration is \(\frac{2500 \text{ mg}}{250 \text{ mL}} = 10 \text{ mg/mL}\).

Calculate dosage in mg/hr

To find how many milligrams are administered per hour, multiply the volume infused per hour by the concentration of the solution. The infusion rate is \(30 \text{ mL/hr}\), and the concentration is \(10 \text{ mg/mL}\). Therefore, the rate of infusion in mg/hr is \(30 \text{ mL/hr} \times 10 \text{ mg/mL} = 300 \text{ mg/hr}\).

Convert mg/hr to mg/min

To convert the dosage from mg/hr to mg/min, divide the dosage by 60, since there are 60 minutes in an hour. Thus, \(\frac{300 \text{ mg/hr}}{60} = 5 \text{ mg/min}\).

Key concepts

Medication Concentration

Medication concentration refers to the amount of a drug in a given volume of solution. Understanding medication concentration is crucial for calculating accurate dosages in medical settings. In the given exercise, Esmolol is mixed into a solution, and the concentration needs to be determined to calculate the correct medication dosage.

To find the concentration, you must know the amount of medication and the total volume of the solution. Here, we have Esmolol at 2.5 grams dissolved in 250 mL of solution. It's essential to convert grams to milligrams, as most dosages are measured in milligrams. Since there are 1000 mg in a gram,
2.5 grams becomes 2500 mg.

Now, simply calculate concentration using the formula:

• Concentration (mg/mL) = Total medication (mg) / Total solution volume (mL)

By substituting in our values, we get a concentration of 10 mg/mL.

Conversion of Units

Converting units is a fundamental skill when calculating dosages. In many medical scenarios, it's necessary to switch between unit types to deliver the correct medication amount.

For the Esmolol dosage calculation, conversion played a key role in understanding the medication concentration by converting grams to milligrams. This conversion was straightforward since 1 gram equals 1000 milligrams.

Moreover, converting from mg/hr to mg/min is necessary in our exercise, as dosage rates can be required in different units. To convert from mg/hr to mg/min, note that there are 60 minutes in an hour. Therefore, divide the hourly dosage by 60.

• Formula = Dosage in mg/hr ÷ 60 = Dosage in mg/min

This skill ensures precision and safety in administering medication.

Infusion Rate Calculation

Infusion rate calculation is the process of determining how much solution should be administered over a specific time. It's particularly important for intravenous medications, like in our Esmolol example.

In the exercise, you're given an infusion rate in mL/hr, specifically, 30 mL/hr. To find out the dosage delivered over time, combine this with the earlier calculated medication concentration of 10 mg/mL.

This step involves a simple multiplication:

• Multiply the infusion rate by the concentration to find the dosage in mg/hr.
• Formula = Infusion rate (mL/hr) × Concentration (mg/mL) = Dosage (mg/hr)

For Esmolol, this multiplication gives 300 mg/hr. Accurately calculating infusion rates helps ensure that patients receive the correct amount of medication.

Step-by-Step Solution

Breaking down problems into smaller steps simplifies complex calculations and ensures precision. Following a step-by-step process helps track your thinking and diagnose any errors.

In our exercise:

• Step 1: Determine Medication Concentration - Convert given units and calculate the concentration in mg/mL.
• Step 2: Calculate Dosage in mg/hr - Use the infusion rate and concentration to get the hourly dosage.
• Step 3: Convert Dosage to mg/min - Adjust the mg/hr figure to a mg/min rate by dividing by 60.

Each step builds on the previous, ensuring that every part of the calculation is correctly completed before moving on to the next task. This methodical approach is crucial in medical scenarios to minimize errors.