Question

Calculate the dosages as indicated. Use the labels where provided. A client is receiving Isuprel \(2 \mathrm{mg}\) in \(250 \mathrm{~mL}\) D5W. The order is to infuse at \(20 \mathrm{~mL} / \mathrm{hr}\). Calculate the following: a. \(\mathrm{mg} / \mathrm{hr}\) b. \(\mathrm{mcg} / \mathrm{hr}\) c. \(\mathrm{mcg} / \mathrm{min}\)

Short answer

a. 0.16 mg/hr; b. 160 mcg/hr; c. 2.67 mcg/min.

Step-by-step solution

Determine the Concentration of the Solution

First, determine how much of the drug is present per milliliter of the solution. Given that you have \(2 \text{ mg}\) of Isuprel in \(250 \text{ mL}\), the concentration is calculated as: \[\text{Concentration} = \frac{2 \text{ mg}}{250 \text{ mL}} = 0.008 \text{ mg/mL}\]

Calculate mg/hr

Next, calculate the dosage in \(\text{mg/hr}\). With the infusion rate at \(20 \text{ mL/hr}\), multiply the concentration by this rate: \[\text{mg/hr} = 0.008 \text{ mg/mL} \times 20 \text{ mL/hr} = 0.16 \text{ mg/hr}\]

Convert mg/hr to mcg/hr

To convert the dosage from \(\text{mg/hr}\) to \(\text{mcg/hr}\), multiply by \(1000\), since there are \(1000\text{ mcg}\) in \(1 \text{ mg}\): \[0.16 \text{ mg/hr} \times 1000 = 160 \text{ mcg/hr}\]

Convert mcg/hr to mcg/min

Finally, to find the dosage in \(\text{mcg/min}\), divide the \(\text{mcg/hr}\) by \(60\), since there are \(60\) minutes in an hour: \[\text{mcg/min} = \frac{160 \text{ mcg/hr}}{60 \text{ min/hr}} \approx 2.67 \text{ mcg/min}\]

Key concepts

Drug Concentration

When calculating dosage, understanding drug concentration is crucial. It refers to the amount of a drug present in a given volume of solution. In our exercise, we have 2 mg of Isuprel dissolved in 250 mL of D5W. To find the concentration, simply divide the total drug quantity by the total volume of the solution. This yields a concentration of \(0.008 \text{ mg/mL}\).
This concentration helps healthcare providers understand how much of the drug a patient receives with each milliliter of solution. Knowing this is essential for accurate medication administration to ensure efficacy and safety.

Infusion Rate

The infusion rate tells us how quickly a drug solution is administered to a patient, usually measured in mL per hour. In this exercise, the rate is set at 20 mL/hr. To find how much drug the patient receives hourly, multiply the concentration by the infusion rate:

• Concentration: \(0.008 \text{ mg/mL}\)
• Infusion Rate: \(20 \text{ mL/hr}\)
• Dosage: \(0.008 \text{ mg/mL} \times 20 \text{ mL/hr} = 0.16 \text{ mg/hr}\)

Understanding the infusion rate ensures that medication is given at the appropriate pace, optimizing therapeutic effects while minimizing potential side effects.

Unit Conversion

Unit conversion is critical in pharmacology to ensure precise administration of drugs. Drug dosages can be expressed in terms of various units, such as mg, micrograms (mcg), or units per time (hr, min). For example, after finding the dosage in mg/hr, we converted it to mcg/hr by multiplying by 1000. This is because 1 mg equals 1000 mcg.
Furthermore, to convert mcg/hr to mcg/min, divide by 60 due to the 60 minutes in an hour:

• \(0.16 \text{ mg/hr} = 160 \text{ mcg/hr}\)
• \(160 \text{ mcg/hr} / 60 = 2.67 \text{ mcg/min}\)

Such conversions are essential for precise dosing, especially in critical care where drugs often require administration in minute quantities.

Pharmacology

Pharmacology is the scientific study of drugs and their effects on living systems. It encompasses the understanding of how drugs work, their uses, and their optimal delivery methods. Calculating dosages, like in the exercise, is an essential part of this field.
Accurate dosage calculations ensure medications are effective while minimizing risks. A good grasp of pharmacological principles, such as drug concentration effects, infusion rates, and unit conversions, enables healthcare professionals to provide better patient care. Additionally, understanding these concepts supports the development of new dosage forms and regimens to meet patient needs.