Question

Calculate the dosages as indicated. Use the labels where provided. A client is receiving nitroglycerin $50\mathrm{mg}$ in $250\mathrm{mL}$ D5W. The order is to infuse $500\mathrm{mcg}/\min$ What flow rate in $\mathrm{mL}/\mathrm{hr}$ would be needed to deliver this amount?

Short answer

The flow rate needed is 150 mL/hr.

Step-by-step solution

Convert Units

First, convert the dosage from micrograms per minute (mcg/min) to milligrams per hour (mg/hr) since the medication is given in milligrams. There are 1000 mcg in 1 mg, and since there are 60 minutes in an hour, convert 500 mcg/min to mg/hr.$$500\text{mcg/min}\times \frac{1\text{mg}}{1000\text{mcg}}\times 60\text{min/hr}=30\text{mg/hr}$$

Determine Concentration of Solution

Determine the concentration of the nitroglycerin solution in mg/mL.$$\text{Concentration}=\frac{\text{Total drug in mg}}{\text{Total fluid in mL}}=\frac{50\text{mg}}{250\text{mL}}=0.2\text{mg/mL}$$

Calculate Flow Rate

To find out the flow rate needed, divide the dosage required per hour by the concentration of the solution:$$\text{Flow rate (mL/hr)}=\frac{30\text{mg/hr}}{0.2\text{mg/mL}}=150\text{mL/hr}$$

Key concepts

Unit Conversion

When dealing with medication dosage calculations, unit conversion is a fundamental step. It's essential to convert units to ensure you administer the correct dose. For example, in the original exercise, the dosage given was in micrograms per minute (mcg/min), but the solution required milligrams per hour (mg/hr). This shift is necessary because the drug concentration provided was in milligrams.

To convert mcg to mg, remember that 1 mg equals 1000 mcg. Therefore, when converting a rate like 500 mcg/min, you'll multiply by 1 mg/1000 mcg. Additionally, converting minutes to hours requires multiplying by 60 since there are 60 minutes in an hour. Here’s how it looks in math:

• Convert 500 mcg/min to mg: $$500\text{mcg/min}\times \frac{1\text{mg}}{1000\text{mcg}}=0.5\text{mg/min}$$
• Convert to mg/hr: $$0.5\text{mg/min}\times 60\text{min/hr}=30\text{mg/hr}$$

Having these conversion skills is vital to accurately calculate medication dosages and ensure patient safety.

Flow Rate Calculation

Flow rate calculation is crucial for determining how quickly a medication should be administered intravenously. It is usually expressed in milliliters per hour (mL/hr).

In the example provided, knowing both the required dose per hour and the drug solution's concentration allows you to compute the flow rate. First, we calculate how much medicine the patient needs each hour—30 mg in this case.The formula to convert this to a flow rate is:$$\text{Flow rate (mL/hr)}=\frac{\text{Dose required (mg/hr)}}{\text{Concentration (mg/mL)}}$$This gives us:

• With a concentration of 0.2 mg/mL, the calculation is:
$$\frac{30\text{mg/hr}}{0.2\text{mg/mL}}=150\text{mL/hr}$$

This means you need to set the IV pump to a flow rate of 150 mL/hr to deliver the correct dosage. Understanding flow rate calculations ensures that patients receive the right amount of medication within the correct timeframe.

Concentration Calculation

Understanding concentration calculations is vital as it informs how much drug is present in a given volume of solution. To determine this, consider both the total drug amount and the fluid volume.

In our given scenario, we calculated concentration with:$$\text{Concentration}=\frac{\text{Total drug in mg}}{\text{Total fluid in mL}}$$For instance:

• With 50 mg of nitroglycerin in 250 mL of solution, we find: $$\frac{50\text{mg}}{250\text{mL}}=0.2\text{mg/mL}$$

Having this concentration value allows healthcare providers to easily determine the correct flow rate needed for medication administration. Accurate concentration calculations are foundational in ensuring medication safety and efficacy.