Question

Adjust intravenous heparin daily based on APTT results. \- APTT less than 35 sec: Rebolus with 80 units/kg and increase rate by 4 units/kg/hr. \- APTT \(35-45\) sec: Rebolus with 40 units/kg and increase rate by 2 units/kg/hr. \- APTT 46-70 sec: No change. \- APTT \(71-90\) sec: Decrease rate by 2 units/kg/hr. \- APTT greater than 90 sec: Stop heparin infusion for 1 hour and decrease rate by 3 units/ \(\mathrm{kg} / \mathrm{hr}\) A client weighs \(100 \mathrm{~kg}\). Determine the bolus dose of heparin, the initial infusion rate, and then adjust the hourly infusion rate up or down based on APTT results using the above weight-based heparin protocol. The APTT is reported as 71 seconds. The pump delivers in whole \(\mathrm{mL} / \mathrm{hr}\).

Short answer

Decrease the infusion rate by 200 units/hr for APTT at 71 seconds.

Step-by-step solution

Determine client's bolus dose and initial infusion rate

The initial bolus and initial infusion rate are not explicitly given, so we will only adjust based on APTT results as per the problem. Given that the client's APTT is 71 sec, we do not need a bolus since no bolus is recommended for this range.

Apply APTT adjustment protocol

The client's APTT is 71 seconds. According to the protocol: - APTT 46-70 sec: No change (not applicable here since we need an adjustment). - APTT 71-90 sec: Decrease rate by 2 units/kg/hr. This means we must adjust the infusion rate by decreasing it by 2 units/kg/hr.

Calculate adjusted infusion rate

Since we are instructed to decrease the rate by 2 units/kg/hr for a client weighing 100 kg, the rate decrease is calculated as follows:\[ \text{Rate decrease} = 2 \times 100 = 200 \text{ units/hr} \]To implement this adjustment, subtract 200 units from the existing rate. The specific initial rate wasn't provided, so adjust based on the current rate.

Key concepts

APTT results

Activated Partial Thromboplastin Time (APTT) is a critical measurement in managing and adjusting intravenous heparin therapy. APTT is a lab test that measures the time it takes for blood to clot, which helps monitor whether the blood-thinning effects of heparin are within the desired therapeutic range.
Analyzing APTT results helps healthcare providers decide whether to increase, decrease, or maintain the heparin dosage. Typically, a standard therapeutic range for APTT while on heparin is between 46 and 70 seconds. This range ensures effective anticoagulation while minimizing the risk of bleeding.
For example, if a patient's APTT is below 35 seconds, it indicates under-anticoagulation, prompting an increase in heparin. Conversely, if APTT exceeds 90 seconds, it suggests excessive anticoagulation, necessitating a reduction in heparin dosage to mitigate bleeding risks. Understanding and interpreting APTT results accurately is a cornerstone of anticoagulation management.

heparin protocol

A heparin protocol is a systematic approach used by healthcare providers to manage heparin dosing based on specific guidelines. It ensures patients receive the right dose to achieve therapeutic anticoagulation safely.
The protocol is designed to quickly adjust heparin dosages in response to changes in a patient's APTT results.
Key elements of this protocol include:

• Initial bolus and infusion rates based on patient-specific factors, such as weight.
• Regular monitoring of APTT to assess anticoagulation levels.
• Clearly defined actions for varying APTT results to either increase, decrease, or maintain heparin doses.

This structured protocol aims to standardize care, reduce the risk of errors, and optimize the therapeutic effects of heparin while keeping patients safe from complications.

infusion rate calculation

Infusion rate calculation is crucial in administering heparin intravenously, especially when APTT results prompt an adjustment. This process entails calculating the precise amount of heparin delivered to the patient per hour.
The infusion rate impacts how effectively the blood is anticoagulated. Any changes required based on APTT results necessitate a precise adjustment of this rate.
For instance, in the provided problem, a patient with an APTT of 71 seconds requires a reduction in the infusion rate by 2 units per kg per hour. If the patient weighs 100 kg, the calculation would be:
\[\text{Decrease in rate} = 2 \text{ units/kg/hr} \times 100 \text{ kg} = 200 \text{ units/hr}\]
The calculated adjustment is then subtracted from the ongoing infusion rate to ensure that the new rate aligns with the therapeutic target. Accurate calculations ensure effective treatment and minimize potential risks.

weight-based dosing

Weight-based dosing is a method used in calculating the appropriate heparin dose for individual patients. This individualized approach considers the patient's body weight to determine both the initial bolus and continuous infusion rates.
This method ensures that the patient receives a dosage that is effective for their body size, optimizing the therapeutic outcome of the anticoagulation process.
Why is weight-based dosing important?

• Ensures that therapeutic effects are achieved without under- or overdosing.
• Reduces the risk of bleeding or clotting complications.
• Offers personalized treatment tailored to the patient's physiological needs.

For example, in the problem provided, a patient weighing 100 kg would start with specific calculations for dose changes based on standard protocols, ensuring safety and efficacy in the treatment regimen.