Question

Calculate the hourly dosage of heparin (units/hr). Order: 20,000 units of heparin in \(500 \mathrm{~mL}\) \(0.45 \% \mathrm{NS}\) to infuse at \(30 \mathrm{~mL} / \mathrm{hr}\).

Short answer

The hourly dosage of heparin is 1200 units/hr.

Step-by-step solution

Determine the concentration of heparin

To find out the concentration of heparin in the solution, divide the total units of heparin by the total volume of the solution. This gives us:\[\text{Concentration} = \frac{20000 \text{ units}}{500 \text{ mL}} = 40 \text{ units/mL}\]

Calculate hourly dosage

To find the hourly dosage of heparin, multiply the concentration (units/mL) by the infusion rate (mL/hr). This gives us:\[\text{Hourly dosage} = 40 \text{ units/mL} \times 30 \text{ mL/hr} = 1200 \text{ units/hr}\]

Key concepts

Understanding Heparin Administration

Heparin is an anticoagulant, which means it helps prevent blood clots. Administering heparin requires careful calculations to ensure the correct dose is delivered. This is important for patient safety and effective treatment.
In our exercise, the physician's order specifies that 20,000 units of heparin should be delivered in a 500-mL bag of 0.45% normal saline (NS).
When giving medications like heparin intravenously, the dosage needs to be precise to help achieve the desired therapeutic effect without causing adverse side effects.
Here are some aspects to consider:

• Calculate the total units: Know the total prescribed units and compare with the supply on hand.
• Assess patient condition: Monitor for signs of bleeding or clotting, which can indicate if the dosage needs adjustment.
• Use the right equipment: Ensure that infusion pumps are calibrated correctly to administer the heparin at the required rate.

Understanding these aspects of heparin administration will help you do it safely and effectively.

Calculating Infusion Rate

The infusion rate determines how fast a medication is delivered to the patient. It's usually measured in milliliters per hour (mL/hr).
In our example, heparin is to be infused at a rate of 30 mL/hr.
The infusion rate is crucial because it controls how quickly the drug enters the bloodstream, affecting its efficacy and safety.
To calculate the infusion rate, follow these steps:

• Verify physician's orders: Ensure they specify the correct rate and total volume.
• Adjust the IV pump: Set the pump to deliver the specified volume per hour.
• Monitor closely: Check the delivery system often to ensure the proper rate is being maintained.

The infusion rate directly affects the hourly dosage of heparin the patient receives, so precision here is vital.

Concentration Calculation Basics

Concentration calculation is a fundamental concept in medical dosages. It relates the amount of a drug to the volume of solution it is in, expressed as units per milliliter (units/mL).
In our given exercise, the concentration of heparin is calculated as follows: For a total of 20,000 units in 500 mL of solution, the concentration is 40 units/mL.
This calculation is crucial because it serves as a basis for determining the correct dosage for administration.
Here's how you do it:

• Calculate concentration: Divide total units by volume ( 20000 ext{ units}/500 ext{ mL} = 40 ext{ units/mL}).
• Verify calculations: Double-check your math to prevent dosing errors.
• Use this for further dosage calculations: Multiply the concentration by the infusion rate to find the hourly dosage.

Mastering concentration calculations can significantly impact therapy outcomes, making them an essential skill in healthcare.