Problem 1
An advertisement in a local newspaper seeks to enroll 20 patients with arthritis in a medical study that would be the first time that a new drug would be tested in persons with this disease. The study would therefore be classified as a (A) Phase I clinical study. (B) Phase II clinical study. (C) Phase III clinical study. (D) Phase IV clinical study. (E) Phase V clinical study.
Problem 2
Which one of the following schedules of controlled substances is for drugs with the highest abuse potential that have a legitimate medical use? (A) Schedule I (B) Schedule II (C) Schedule III (D) Schedule IV (E) Schedule V
Problem 3
The 4th to the 10 th week of gestation is the period of time when there is the greatest concern about drug-induced (A) fetal cardiac arrest. (B) fetal hemorrhage. (C) fetal malformations. (D) labor. (E) fetal jaundice.
Problem 4
Which of the following drug interaction mechanisms is most likely to lead to sustained elevations of plasma drug concentrations and drug toxicity? (A) induction of CYP2C19 (B) inhibition of CYP3A4 (C) displacement of a drug from plasma albumin-binding sites (D) inhibition of the P-glycoprotein carrier protein (E) acceleration of gastric emptying by a "prokinetic" drug
Problem 5
Elderly persons may have altered drug disposition because of (A) a markedly reduced absorption of many drugs. (B) higher volumes of distribution for water-soluble drugs. (C) an accelerated renal excretion of ionized drugs. (D) an increased permeability of the blood-brain barrier. (E) a reduced capacity to oxidize drugs.
