Problem 1
If food decreases the rate but not the extent of the absorption of a particular drug from the gastrointestinal tract, then taking the drug with food will result in a smaller (A) area under the plasma drug concentration time curve. (B) maximal plasma drug concentration. (C) time at which the maximal plasma drug concentration occurs. (D) fractional bioavailability. (E) total clearance.
Problem 2
If a drug exhibits first-order elimination, then (A) the elimination half-life is proportional to the plasma drug concentration. (B) the drug is eliminated at a constant rate. (C) hepatic drug metabolizing enzymes are saturated. (D) drug clearance will increase if the plasma drug concentration increases. (E) the rate of drug elimination \((\mathrm{mg} / \mathrm{min})\) is proportional to the plasma drug concentration.
Problem 3
After a person ingests an overdose of an opioid analgesic, the plasma drug concentration is found to be \(32 \mathrm{mg} / \mathrm{L}\). How long will it take to reach a safe plasma concentration of \(2 \mathrm{mg} / \mathrm{L}\) if the drug's half-life is 6 hours? (A) 12 hours (B) 24 hours (C) 48 hours (D) 72 hours (E) 1 week
Problem 4
What dose of a drug should be injected intravenously every 8 hours to obtain an average steady-state plasma drug concentration of \(5 \mathrm{mg} / \mathrm{L}\) if the drug's volume of distribution is \(30 \mathrm{~L}\) and its clearance is \(8 \mathrm{~L} / \mathrm{h}\) ? (A) \(40 \mathrm{mg}\) (B) \(80 \mathrm{mg}\) (C) \(160 \mathrm{mg}\) (D) \(320 \mathrm{mg}\) (E) \(400 \mathrm{mg}\)
Problem 5
The volume of distribution of a drug will be greater if the drug (A) is more ionized inside cells than in plasma. (B) is administered very rapidly. (C) is highly ionized in plasma. (D) has poor lipid solubility. (E) has a high molecular weight.
