Problem 1
Which of the following molecular processes best describes the mechanism of action of benzodiazepines? (A) potentiating the effect of GABA at chloride ion channels (B) blocking glutamate excitation (C) blocking the inactivation of sodium ion channels (D) binding to opioid receptors to produce sedation (E) potentiating the action of the inhibitory amino acid, glycine
Problem 2
Benzodiazepines are noted for altering which one of the following aspects of sleep? (A) increasing the time to sleep onset (B) decreasing stage 2 NREM sleep (C) increasing slow-wave sleep (D) decreasing the REM stage of sleep (e) increasing sleep awakenings
Problem 3
Which one of the following statements best describes flumazenil? (A) does not produce withdrawal seizures (B) has the longest elimination half-life (C) is not metabolized into an active agent (D) is also used for the treatment of epilepsy (E) is a selective benzodiazepine antagonist
Problem 4
Zaleplon differs from zolpidem in which one of the following ways? (A) produces withdrawal seizures (B) has a shorter elimination half-life (C) has a different chemical structure than benzodiazepines (D) shows less tolerance to sedative effects (E) produces greater morning sedation
Problem 5
Which one of the following anxiolytic drugs is noted for its lack of sedation? (A) hydroxyzine (B) diazepam (C) oxazepam (D) alprazolam (E) buspirone
