Question

Which mechanism is responsible for the vasodilation effect of verapamil? (A) increased levels of cGMP (B) decreased binding of calcium to calmodulin (C) decreased formation of \(\mathrm{IP}_3\) (D) increased myosin light-chain kinase activity (E) increased metabolic efficiency

Short answer

Verapamil causes vasodilation by (B) decreased binding of calcium to calmodulin.

Step-by-step solution

Identify the Mechanism of Verapamil

Verapamil is known as a calcium channel blocker, specifically acting on L-type calcium channels. This drug works by inhibiting the influx of calcium ions into the cells.

Understand Calcium's Role in Vasodilation

In vascular smooth muscle cells, calcium ions usually bind to calmodulin. This complex activates myosin light-chain kinase (MLCK), leading to muscle contraction. By blocking calcium, verapamil limits this pathway, preventing contraction and causing vasodilation.

Analyze the Options

Option (B) "decreased binding of calcium to calmodulin" relates to verapamil's action because it directly results from the reduced calcium influx. The other options do not correspond to its primary mechanism.

Select the Correct Answer

Given that verapamil reduces the calcium available to bind to calmodulin, the correct answer is (B) decreased binding of calcium to calmodulin.

Key concepts

Calcium Channel Blockers

Calcium channel blockers are a class of medications commonly used to manage cardiovascular diseases. They play a crucial role in relaxing blood vessels and reducing heart rate by influencing the calcium ion movement across cell membranes.
Verapamil is one of these medications and specifically targets L-type calcium channels. By blocking these channels, verapamil prevents calcium ions from entering the cells, particularly in the heart and smooth muscle of blood vessels.
Without calcium ions, muscles cannot contract as effectively, which helps in reducing blood pressure and workload on the heart.
Core functions of calcium channel blockers include:

• Lowering arterial pressure.
• Decreasing heart rate and effort.
• Causing vasodilation, leading to improved blood flow.

This mechanism proves highly beneficial in treating high blood pressure, angina, and certain arrhythmias.

Vasodilation

Vasodilation refers to the widening or relaxing of blood vessels, which results in increased blood flow and decreased blood pressure.
The role of vasodilation in the cardiovascular system is vital because it helps to reduce the workload of the heart and facilitates better oxygen delivery to tissues.
When medications like verapamil inhibit the entry of calcium into vascular smooth muscle cells, the usual contraction signal is interrupted. As a result, the smooth muscle relaxes and dilates the blood vessels.
This process can significantly help in conditions like hypertension and angina by enabling more efficient circulation and reducing heart strain. In essence, vasodilation helps maintain proper balance in blood pressure and flow.

L-type Calcium Channels

L-type calcium channels are a type of voltage-dependent calcium channel prominent in cardiac and smooth muscle cells.
They are crucial for the contraction process in muscles, as they allow calcium ions to enter the cells upon activation. The presence of these ions is essential for the contraction mechanism.
In the heart, L-type calcium channels are responsible for the plateau phase of the cardiac action potential, promoting proper heart function.
When verapamil blocks these channels, it interrupts the cascade of events necessary for muscle contraction. The blockade occurs mainly in the vascular smooth muscle and cardiac cells, facilitating the vasodilatory effects by reducing calcium availability.
Understanding these channels' functionality provides insights into how calcium channel blockers like verapamil achieve their therapeutic effects.