Question

Which of the following correctly describes the intramuscular route of parenteral drug administration? (A) drug absorption is erratic and unpredictable (B) used to administer drug suspensions that are slowly absorbed (C) bypasses the process of drug absorption to achieve an immediate effect (D) cannot be used for drugs that undergo a high degree of first-pass metabolism (E) poses more risks than intravenous administration

Short answer

The correct description is (B): used to administer drug suspensions that are slowly absorbed.

Step-by-step solution

Understand the Intramuscular Route

The intramuscular (IM) route involves injecting a drug directly into a muscle. This allows the drug to be absorbed into the surrounding blood vessels and tissues, typically resulting in a slower and more controlled release than direct intravenous administration.

Analyze Each Option

Option (A) suggests erratic absorption, which is not generally true for the IM route as it is more predictable than subcutaneous or oral administration. Option (B) indicates the use for drug suspensions with slow absorption, which is a common and correct use for the IM route. Option (C) describes immediate effect by bypassing absorption. This is more applicable to intravenous administration. Option (D) indicates use limitations for drugs with high first-pass metabolism. This is incorrect as IM does not imply metabolic transformation by the liver. Option (E) implies more risks than intravenous administration, which is not typical since intravenous routes often pose higher immediate risks.

Determine the Correct Description

Based on the analysis, option (B) correctly describes the intramuscular route as it is commonly used to administer drug suspensions that are slowly absorbed, allowing for a more sustained release of the drug.

Key concepts

Intramuscular Drug Administration

Intramuscular drug administration is a popular method for delivering medications directly into muscle tissue. This technique makes use of the rich blood supply in muscle, allowing the medication to be absorbed gradually into the bloodstream and providing a steady effect. Administering drugs intramuscularly is used when patients require slow absorption and sustained action of the medication.
This route is often used for vaccines, hormones, and medications that are formulated in a suspension, making it ideal for drugs that are released slowly over time. Advantages of this method include:

• Better control over drug absorption rate compared to oral or subcutaneous routes.
• No need for digestive processes which can degrade some drugs.
• Reducing the potential for irritation that might occur with other administration routes.

Performing an intramuscular injection involves specific muscle sites such as the deltoid, thigh, or hip, which are selected based on drug volume and patient comfort.

Parenteral Drug Administration

Parenteral drug administration involves delivering medications through routes other than the digestive tract, meaning bypassing the gastrointestinal system for direct entry into the circulatory system. This is beneficial due to a variety of reasons:

• Fast onset of action as the drug is immediately available in the systemic circulation.
• Avoidance of first-pass metabolism which can modify or reduce the efficacy of drugs taken orally.
• Suitable for patients who cannot take oral medication, such as those with gastrointestinal disorders.

Common routes of parenteral administration include intravenous (IV), intramuscular (IM), and subcutaneous injections. Each route has its own specific advantages and is chosen based on the specific drug, desired speed of effect, and patient needs. Overall, parenteral administration provides a valuable option for delivering medications with precision and often better bioavailability than oral routes.

Drug Absorption Mechanisms

Drug absorption mechanisms are vital for understanding how medications achieve their therapeutic effects. Absorption is the process by which a drug moves from its site of administration into the bloodstream. When it comes to intramuscular injections, the absorption takes several factors into account:

• The affinity of the drug to the muscle tissue and blood supply which facilitates gradual uptake into the system.
• The formulation of the drug, such as whether it is a solution or a suspension, which affects the rate at which it becomes available in the circulation.
• Circulatory dynamics which vary between individuals, influencing drug bioavailability.

Unlike oral drugs, intramuscular and other parenteral routes do not encounter stomach acid or enzymatic degradation. This leads to more predictable absorption curves and can often result in a more consistent and prolonged therapeutic effect. Understanding these mechanisms highlights the importance of appropriate route selection for achieving the desired drug efficacy.