Question

How would increased airway resistance affect intrapleural pressure during inhalation?

Short answer

Increased resistance in the airways (bronchi) can lead to airway compression.

Step-by-step solution

Step 1. Introduction 

Intrapleural pressure refers to the pressure within the pleural cavity. Normally, the pressure within the pleural cavity is slightly less than the atmospheric pressure, which is known as negative pressure.

Step 2. Explanation 

Increased airway resistance affects the volume and the pressure inside the lung; therefore, the intrapleural pressure would be less negative and breathing would be more difficult.

During inspiration, the diaphragm and the inspiratory intercostal muscles actively contract, leading to the expansion of the thorax. The intrapleural pressure becomes more subatmospheric or more negative.