Question

An adult with a history of tanning has his genome sequenced. The beginning of a protein-coding region of his DNA reads ATGGGGATATGGCAT. If the protein-coding region of a healthy adult reads ATGGGGATATGAGCAT, identify the site and type of mutation.

Short answer

At 12 position A is deleted and it is a frameshift mution.

Step-by-step solution

Step 1. Introduction

Frameshift mutation involves the insertion and deletion of the base, which alter the entire reading frame of the message.

Step 2. Explanation

It is a frameshift mutation as at the 12th position of the coding region Adenine is deleted.

• Patient: ATGGGGATATGGCAT
• Normal adult: ATGGGGATATGAGCAT