Question

How does citrate from the citric acid cycle affect glycolysis?

Short answer

As a result, citrate from the citric acid cycle functions as a negative regulator for the glycolysis enzyme phosphofructokinase.

Step-by-step solution

step-1: definition

Glycolysis is the initial stage in cellular respiration, and it occurs in both eukaryotes and prokaryotes' cytoplasm.

step-2: Introduction

One molecule of glucose is broken down enzymatically into two molecules of pyruvate, NADH (Reduced Nicotinamide Adenine Dinucleotide Hydrogen), and ATP in this catabolic process (adenosine triphosphate)

step-3: Explanation

The pyruvate produced in glycolysis is oxidized to make acetyl CoA, which is a starting material for the citric acid cycle, the second step of cellular respiration. It's an acyclic process that transforms one molecule of acetyl CoA into two molecules of , molecules of NADH and one molecule of GTP and in the mitochondria aerobically.

By feedback inhibition, citrate, the first product of the citric acid cycle, inhibits the phosphofructokinase enzyme (the ratelimiting enzyme of glycolysis). When the citrate level in the cell rises, glycolysis slows down because the biosynthetic precursors are sufficient and do not require any further degradation of glucose. As a result, the product "feeds back" to close the pathway.