Chapter 9: Q. 32 (page 252)
How does the extracellular matrix control the growth of cells?
If receptors are not in touch with the cell, appropriate functioning will not occur, leading to cell death.
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A scientist observes a mutation in the transmembrane region of EGFR that eliminates its ability to be stabilized by binding interactions during dimerization after ligand binding. Which hypothesis regarding the effect of this mutation on EGF signaling is most likely to be correct?
a. EGF signaling cascades would be active for longer in the cell.
b. EGF signaling cascades would be active for a shorter period of time in the cell.
c. EGF signaling cascades would not occur.
d. EGF signaling would be unaffected.
What would happen if the intracellular domain of a cellsurface receptor was switched with the domain from another receptor?
Why are ion channels necessary to transport ions into or out of a cell?
a. Ions are too large to diffuse through the membrane.
b. Ions are charged particles and cannot diffuse through the hydrophobic interior of the membrane.
c. Ions do not need ion channels to move through the membrane.
d. Ions bind to carrier proteins in the bloodstream, which must be removed before transport into the cell.
Where do DAG and IP3 originate?
a. They are formed by phosphorylation of cAMP.
b. They are ligands expressed by signaling cells.
c. They are hormones that diffuse through the plasma
membrane to stimulate protein production.
d. They are the cleavage products of the inositol phospholipid, PIP2.
What property prevents the ligands of cell-surface receptors from entering the cell?
a. The molecules bind to the extracellular domain.
b. The molecules are hydrophilic and cannot penetrate the hydrophobic interior of the plasma membrane.
c. The molecules are attached to transport proteins that deliver them through the bloodstream to target cells.
d. The ligands are able to penetrate the membrane and directly influence gene expression upon receptor binding.
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