Question

Histamine binds to the H1 G-protein-linked receptor to initiate the itchiness and airway constriction associated with an allergic response. If a mutation in the associated G-protein’s alpha subunit prevented the hydrolysis of GTP how would the allergic response change? a. More severe allergic response compared to normal G-protein signaling. b. Less severe allergic response compared to normal G-protein signaling. c. No allergic response. d. No change compared to normal G-protein signaling.

Short answer

The correct option is a.

Step-by-step solution

Step 1. Introduction

Histamine is a chemical substance that is produced by the body during injury. It is a chemical messenger that help to mediate various cellular responses like allergy, inflammation, gastric reaction, or limited neurotransmitter action in the brain.

Step 2. Explanation of the correct option.

Option a is correct because G protein-linked receptors are bound with histamine to convert extracellular signals into intracellular responses like inchness or allergies. if mutation occur in this receptors then there will be more severe allergic responses.

Step 3. The explanation of the incorrect options

Option b is incorrect because if GTP hydrolysis is prevented then there will be a more severe allergic response.

Option c is incorrect because there will be a severe allergic response if hydrolysis of GTP is prevented.

Option d is incorrect because there will be a severe allergic response as compared to normal G-protein signaling.