Genetic drift affects small populations more severely than larger ones. In small populations, each individual's genetic makeup has a larger relative impact on the population's allele frequencies compared to a large population. Thus, any random event that affects allele frequencies can have a bigger sway.
It's like flipping a coin a small number of times versus thousands of times. With fewer flips, there's a greater chance of straying from an even 50/50 distribution. Similarly, in small populations, a chance event—such as a few individuals who carry rare alleles leaving offspring or not—can shift the population's allele frequencies quickly and drastically.
- Genetic drift can lead to alleles becoming fixed: where an allele becomes the only one present within a population.
- Conversely, genetic drift can cause alleles to disappear completely.
These effects underline why genetic variability is often lower in small, isolated populations.