Chapter 21: Problem 6
How is determination distinct from differentiation?
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Key Concepts
These are the key concepts you need to understand to accurately answer the question.
Chapter 21: Problem 6
How is determination distinct from differentiation?
These are the key concepts you need to understand to accurately answer the question.
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Get started for freeMany of the proteins used to induce differentiation in human iPS cells also work to differentiate mouse iPS cells. Why is this ability of a human protein to work in mouse cells not a surprise?
What are iPS cells? a. cells taken from early human embryos b. cells taken from the pancreas of people without diabetes c. cells derived by de-differentiating specialized adult cells d. cells derived by differentiating pancreas precursor cells
A research team has explored the possibility of differentiating human embryonic stem (hES) cells into pancreatic cells that might be used to treat diabetes. In contrast to iPS cells, hES cells are taken from an early human embryo, and obtaining them destroys the embryo. The team showed that cells differentiated from hES cells could cure diabetes in a mouse model of the disease. If the same outcome of curing diabetes could be achieved in humans, would there be any advantage to starting with hES or iPS cells to produce pancreatic cells in order to gain widespread acceptance of this therapeutic approach? Why?
Imagine a situation in which a morphogen has its source at the posterior end of a Drosophila embryo. Every \(100 \mu \mathrm{m}\) from the posterior pole, the morphogen concentration decreases by half. If a cell required \(1 / 16\) th the amount of morphogen found at the posterior pole to form part of a leg, how far from the posterior pole would the leg form? a. \(100 \mu \mathrm{m}\) b. \(160 \mu \mathrm{m}\) c. \(400 \mu \mathrm{m}\) d. \(1600 \mu \mathrm{m}\)
Which of the following provides the strongest evidence for the conservation of tool-kit genes? a. Bicoid moved from one fly embryo into the posterior of another fly embryo causes the formation of two head regions. b. Mutation of an unrelated gene in another species of fly has a similar effect to mutation of bicoid in Drosophila. c. A mouse Hox gene can be used to take over the function of a mutated Drosophila Hox gene. d. Sheep can be cloned by fusing a differentiated adult cell with an enucleated egg.
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