Chapter 19: Problem 13
What explains the often-encountered side effect of "acetone breath" on dieters following a very strict low-carbohydrate diet such as the Atkins Diet?
Chapter 19: Problem 13
What explains the often-encountered side effect of "acetone breath" on dieters following a very strict low-carbohydrate diet such as the Atkins Diet?
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Get started for freeTreatment of type 2 diabetes to lower blood glucose includes the use of sulfonylureas, which stimulate insulin secretion, and metformin, which inhibits gluconeogenesis. Explain the biochemical rationale behind the use of each drug.
One of the effects of leptin in nonadipose tissue is to upregulate the synthesis of uncoupler protein. How might this effect help prevent obesity?
A variety of metabolic parameters affect homeostatic blood glucose levels. For each of the altered metabolic conditions listed below, predict if it would result in higher or lower blood glucose levels compared to that of the normal metabolic condition. a. Amino acids are not efficiently converted to keto acids during starvation. b. Glycogen debranching enzyme does not function during intense exercise. c. The glucagon receptor is always active, even in the absence of glucagon. d. The enzyme pyruvate carboxylase is expressed at abnormally high levels. e. Pancreatic \(\alpha\) cells do not secrete functional glucagon.
After short-term vigorous anaerobic exercise, you continue to breathe rapidly for some time. The oxygen consumed during this period is called the oxygen debt and is equal to the amount of oxygen that would have been consumed if the exercise had been completely aerobic. What is the oxygen debt used for in muscle and liver cells?
Leptin is an adipocyte hormone that sends signals to the brain to "eat less" and "metabolize more." What is the explanation for why leptin injections cause weight loss in the strain of OB mutant mice, but leptin injections have no effect in the majority of obese people? Is this observation analogous to type 1 or type 2 diabetes? Explain.
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