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Monosaccharides
Monosaccharides are simple carbohydrates. They are also called simple sugars, since they are composed of one molecule of sugar (mono- meaning ‘one’, and -sacchar meaning ‘sugar’).
They are hydrophilic, meaning they are soluble in water. They are building blocks (monomers) of larger molecules of carbohydrates: polysaccharides (polymers).
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As explained in the article on carbohydrates, monosaccharides are organic molecules composed of carbon, hydrogen and oxygen atoms. They can be shown in their linear or ring structure. Have a look at figures 1 and 2, which show the two structures of the same molecule.
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Monosaccharides are categorised according to how many atoms of carbon they contain. These are the three most common types:
Trioses (3 Carbon atoms) are important in cellular respiration.
Pentoses (5 Carbon atoms), for example, ribose in RNA and deoxyribose in DNA.
Hexoses (6 Carbon atoms), like glucose, fructose, and galactose.
Figure 3 shows you the difference between trioses, pentoses, and hexoses. Notice how the linear structure gets lengthens as more carbon atoms are added.
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Fig. 3 - Examples of triose, pentose, and hexose sugars. Observe the carbon backbone
Examples of monosaccharides
You will come across three monosaccharides classed as the most important in nutrition: glucose, galactose, and fructose. However, these are not the only ones. Deoxyribose and ribose are of great importance too, being the bases of DNA and RNA.
Glucose
Glucose is the most common monosaccharide. Along with oxygen, it is the product of photosynthesis. It is an important energy source for both animals and plants.
The molecular formula for glucose:
This tells you that it has 6 carbon atoms, meaning glucose is a hexose.
Glucose has two isomers: α-glucose (alpha-glucose) and β-glucose (beta-glucose). They have the same molecular formula. However, they differ in structure. There is a slight difference in the arrangement of atoms in the molecule. Notice the position of the far-right hydrogen atom (H) and the hydroxyl group (OH) in figure 4.
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Galactose is found in milk, while fructose is found in fruit. They are similar to glucose in that all three share the same formula: However, similar to α-glucose and β-glucose, they differ in structure. In figure 5, notice how atoms and groups are arranged in all three sugars.
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Fig. 5 -The linear form of the structures of glucose, galactose, and fructose
Deoxyribose and ribose
Another two very important monosaccharides are deoxyribose and ribose. They are found in DNA and RNA respectively, where they are bases of nucleotides, which carry genetic material.
Both deoxyribose and ribose are pentoses, meaning they consist of 5 carbon atoms. The formula for deoxyribose is and ribose is . Notice the arrangement of the atoms in figure 6.
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Monosaccharides form disaccharides and polysaccharides
Monosaccharides are joined together in a process called condensation. The condensation reaction of certain monosaccharides results in the formation of disaccharides and polysaccharides. In disaccharides, two monosaccharides are bonded, while in polysaccharides, there are many (poly- stands for ‘many’).
A condensation reaction between two monosaccharides forms a covalent, glycosidic bond. There are different types of glycosidic bonds that form between monosaccharides. Depending on the placement of the bonds, there are, for example, 1,4-glycosidic bonds that form on the 1st carbon atom of one and the 4th carbon atom of the other monosaccharide. You will come across 1,6-glycosidic bonds in polysaccharides as well, where branches are formed in the chains.
Remember that there are two different glucose isomers: α-glucose and β-glucose. Depending on which isomer forms a certain disaccharide or polysaccharide, these bonds can be written as α-1,4-glycosidic bonds or β-1,4-glycosidic bonds. The same goes for 1,6 bonds.
You may notice that we have used certain next to monosaccharides instead of all monosaccharides in the text above. This is because deoxyribose and ribose do not attach to one another to form disaccharides and polysaccharides, even though they are monosaccharides. Instead, they are the sugar bases of nucleotides, monomers of DNA and RNA. During the condensation reaction of nucleotides to the 3’ carbon atom on deoxyribose or ribose, a phosphate group is attached and two nucleotides are joined together. You can learn more about this in the article on nucleic acids.
Disaccharides and polysaccharides can be broken down into monosaccharides during hydrolysis. This is a reaction in which water molecules are added and the glycosidic bonds between monosaccharides are broken. This results in the breaking down of disaccharides and polysaccharides.
Monosaccharides - Key takeaways
Monosaccharides are simple carbohydrates composed of one molecule of sugar and are the building blocks (monomers) of larger molecules of carbohydrates: polysaccharides (polymers).
Monosaccharides are categorised according to how many atoms of carbon they contain: trioses (3 carbon atoms), pentoses (5 carbon atoms), for example, ribose in RNA and deoxyribose in DNA, and hexoses (6 carbon atoms), like glucose, fructose, and galactose.
Glucose is the most common monosaccharide. It has two isomers: α-glucose (alpha-glucose) and β-glucose (beta-glucose). They have the same molecular formula C6H12O6. However, they differ in the arrangement of atoms in the molecule: the position of the far-right hydrogen atom (H) and the hydroxyl group (OH).
Another two very important monosaccharides are deoxyribose and ribose. They are found in DNA and RNA.
Monosaccharides join together in a process called condensation. The covalent glycosidic bond forms between monosaccharides, with molecules of water removed.
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Frequently Asked Questions about Monosaccharides
What is a monosaccharide?
A monosaccharide is a simple carbohydrate. It is an organic biological molecule composed of one molecule of sugar. Monosaccharides are building blocks (monomers) of larger molecules of carbohydrates (polymers).
Is glucose a monosaccharide?
Yes, glucose is a monosaccharide and the most common of them all.
Is lactose a monosaccharide?
No, lactose is a disaccharide composed of two monosaccharides: glucose and galactose.
What are the three monosaccharides?
The three monosaccharides are glucose, fructose, and galactose.
What monosaccharides make up starch?
The monosaccharide that makes up starch is glucose.
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